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Synthesis and in vitro cytotoxic evaluation of new triazole derivatives based on artemisinin via click chemistry

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Abstract

The paper presents the synthesis of new artemisinin triazole derivatives via click chemistry and their in vitro cytotoxic evaluation against four cancer cell lines including MCF-7, LU-1, HL-60 and P388. The bioassay result showed that most of the target compounds were active against four cell lines, in which compounds 11g displayed the most potent inhibitory activity against HL-60 cell line with IC50 value of 2.5 μM.

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Acknowledgments

The authors thank Vietnam National Foundation for Science and Technology Development (NAFOSTED) for financial support via a Project 104.01.2013.01.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry and Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet Street, Hai Ba Trung District, Hanoi, Vietnam

    Le Huy Binh, Nguyen Thi Thuy Van, Vu Tuan Kien, Nguyen Thi Thuy My, Hoang Xuan Tien & Tran Khac Vu

  2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

    Luu Van Chinh & Nguyen Thi Nga

  3. Laboratory for Bioassay, Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

    Do Thi Thao

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  1. Le Huy Binh
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  2. Nguyen Thi Thuy Van
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Correspondence to Tran Khac Vu.

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Binh, L.H., Van, N.T.T., Kien, V.T. et al. Synthesis and in vitro cytotoxic evaluation of new triazole derivatives based on artemisinin via click chemistry. Med Chem Res 25, 738–750 (2016). https://doi.org/10.1007/s00044-016-1524-z

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  • DOI: https://doi.org/10.1007/s00044-016-1524-z

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