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Synthesis, characterization, and antitumor activity of binuclear curcumin–metal(II) hydroxo complexes

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Abstract

Binuclear curcumin–M(II) (M, Cu, Zn, Cd) hydroxo complexes, obtained by the reaction of metal (II) nitrate and curcumin in a 1:2 mol ratio were characterized by elemental analysis, FTIR, UV, and mass spectroscopy. Mechanism of reaction was elucidated showing that curcumin catalyzes hydroxyl formation in the presence of the oxolating nitrate groups. Cytotoxic activities of curcumin alone and the three complexes against a panel of four cancer cell lines, MCF-7, HEPG2, Hela, and HCT-116, was investigated in vitro. Curcumin alone was found to be more effective as an anticancer agent compared to the metal-complexed curcumin.

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Acknowledgments

This project was supported by King Saud University, Deanship of Scientific Research, College of Science Research Center.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia

    Mutasim I. Khalil, Aisha M. AL-Zahem & Maha M. Qunaibit

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  1. Mutasim I. Khalil
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  2. Aisha M. AL-Zahem
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  3. Maha M. Qunaibit
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Correspondence to Mutasim I. Khalil.

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Khalil, M.I., AL-Zahem, A.M. & Qunaibit, M.M. Synthesis, characterization, and antitumor activity of binuclear curcumin–metal(II) hydroxo complexes. Med Chem Res 23, 1683–1689 (2014). https://doi.org/10.1007/s00044-013-0727-9

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