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Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives

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Abstract

A series of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives (1–18) was synthesized and tested in vitro for its anti-microbial potential. The results of anti-microbial studies indicated that derivatives having 3,4,5 trimethoxy (6) and 2,4 dichloro (17) groups on benzylidene amino portion were found to be most effective ones. The mt-QSAR model for anti-microbial activity revealed the importance of topological parameter, valence zero-order molecular connectivity index (0χv) in describing the anti-microbial activity of synthesized 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives.

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  1. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

    Rajesh Kumar, Pradeep Kumar, Mahesh Kumar & Balasubramanian Narasimhan

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  1. Rajesh Kumar
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  2. Pradeep Kumar
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Correspondence to Balasubramanian Narasimhan.

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Kumar, R., Kumar, P., Kumar, M. et al. Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives. Med Chem Res 21, 4301–4310 (2012). https://doi.org/10.1007/s00044-011-9954-0

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