Abstract
A novel series of N-substituted 2-phenyl indole derivatives incorporating barbituric acid have been synthesised and the chemical structures of the resulting molecules were characterised by means of IR, NMR and mass spectra. The antimicrobial activities of these compounds were investigated. Significant improvement in the antimicrobial activity can be achieved, in the presence of Cl and Br substituents on phenacyl moiety at para position. Single crystal X-ray analysis was also performed for the compound 6b in order to determine the crystal structure.
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Acknowledgments
The authors wish to thank Dr. B. Srinivas, NIT Warangal for interpreting the single crystal X-ray analysis, one of the authors S.V thanks the Ministry of Human Resource Development for providing the fellowship.
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The author reports no conflicts of interest. The author alone hereby stands responsible for the contents of this scientific paper.
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Laxmi, S.V., Janardhan, B., Rajitha, B. et al. Synthesis, single crystal X-ray studies and antimicrobial activities of novel Indole barbiturates. Med Chem Res 21, 2896–2901 (2012). https://doi.org/10.1007/s00044-011-9827-6
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DOI: https://doi.org/10.1007/s00044-011-9827-6