Abstract
A new series of N-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (3a–h) and N-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene)hydrazinecarbothioamides (5a–h) were synthesized and characterized by IR, 1H NMR, mass and elemental analysis. In vivo anticonvulsant and acute toxicity screening of all the synthesized compounds showed morpholino (3f) and imidazolyl (3g) derivatives as promising anticonvulsant lead. Furthermore, In silico drug-likeness parameters have also been investigated for filtering out the likelihood of poor drug absorption or brain penetration. 3D four-point pharmacophore measurements of compounds were also carried out to match these with established anticonvulsants agents.
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Acknowledgments
The author Asif S. deeply acknowledges the University Grants Commission, India, for providing the Junior Research Fellowship. The authors also wish to express their thanks to Hamdard University, New Delhi, India for providing animal research facilities.
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Amir, M., Asif, S., Ali, I. et al. Synthesis of benzothiazole derivatives having acetamido and carbothioamido pharmacophore as anticonvulsant agents. Med Chem Res 21, 2661–2670 (2012). https://doi.org/10.1007/s00044-011-9791-1
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DOI: https://doi.org/10.1007/s00044-011-9791-1