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Transition metal complexes of thiosemicarbazones with quinoxaline hub: an emphasis on antidiabetic property

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Abstract

New transition metal complexes of quinoxaline–thiosemicarbazone ligands were prepared and characterised by spectroanalytical techniques. The ligands L1H2 and L2H2 were obtained by the reaction of quinoxaline-2.3(1,4H)-dione with methyl and phenyl thiosemicarbazide, respectively. All the complexes are found to be monomeric in nature and have tetrahedral geometry. The copper complexes have shown redox responses in the applied voltage range, whereas the ligands and other complexes are electrochemically innocent. The ligands, copper and zinc complexes are explored for antidiabetic activity in the diabetes-induced Wister rats. Evaluation of antidiabetic activity was done by blood-glucose test and oral glucose tolerance test; few compounds have exhibited significant antidiabetic activity and posses low toxicity with a high safety profile.

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Acknowledgments

The authors thank Department of Chemistry and USIC, Karnatak University, Dharwad for the spectral facility. Recording of FAB-mass spectra (CDRI Lucknow) are gratefully acknowledged. Further, the author (Naveen V. Kulkarni) thank Karnatak University, Dharwad for providing Nilekani fellowship.

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Authors and Affiliations

  1. Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, 580 003, Karnataka, India

    Naveen V. Kulkarni & Vidyanand K. Revankar

  2. Basaveshwar Science College, Bagalkot, 587 101, Karnataka, India

    B. N. Kirasur

  3. Luqman College of Pharmacy, Gulbarga, 585 102, Karnataka, India

    Mallinath H. Hugar

Authors
  1. Naveen V. Kulkarni
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  2. Vidyanand K. Revankar
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  3. B. N. Kirasur
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  4. Mallinath H. Hugar
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Correspondence to Vidyanand K. Revankar.

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Kulkarni, N.V., Revankar, V.K., Kirasur, B.N. et al. Transition metal complexes of thiosemicarbazones with quinoxaline hub: an emphasis on antidiabetic property. Med Chem Res 21, 663–671 (2012). https://doi.org/10.1007/s00044-011-9576-6

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  • DOI: https://doi.org/10.1007/s00044-011-9576-6

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