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Synthesis and antiviral activity of benzimidazolyl- and triazolyl-1,3,5-triazines

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Abstract

A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 μg/ml, SI = 358; for compound 5r: EC50 = 5.0 μg/ml, SI = 300) in comparison to acyclovir.

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Acknowledgments

This study was supported by Mansoura University research grant. The authors would like to thank Dr El-Sayed E. Habib, Department of Microbiology, Faculty of Pharmacy, Mansoura University for his assistance in performing the biological testing at the Department of Pediatrics, Medical College of Virginia, Virginia Commenwealth University, USA.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Azza R. Maarouf

  2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Abdelbasset A. Farahat, Khalid B. Selim & Hassan M. Eisa

Authors
  1. Azza R. Maarouf
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  2. Abdelbasset A. Farahat
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  3. Khalid B. Selim
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  4. Hassan M. Eisa
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Correspondence to Hassan M. Eisa.

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Maarouf, A.R., Farahat, A.A., Selim, K.B. et al. Synthesis and antiviral activity of benzimidazolyl- and triazolyl-1,3,5-triazines. Med Chem Res 21, 703–710 (2012). https://doi.org/10.1007/s00044-011-9574-8

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  • DOI: https://doi.org/10.1007/s00044-011-9574-8

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