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Anti-inflammatory and antioxidant activities of some extracts and pure natural products isolated from Rhus tripartitum (Ucria)

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Abstract

Chromatographic separation of Rhus tripartitum (Anacardiaceae) chemical components revealed the presence of four main natural substances: a new biflavonoid masazinoflavanone (S1), myricetin (S2), (-)-lyoniresinol 3α-O-β-D-glucopyranoside (S3), and (-)-methyl shikimate (S4). The anti-inflammatory activity of the new biflavonoid substance was performed. Compared with the standard drug dexamethasone, the biflavonoid substance masazinoflavanone (S1) inhibited in a dose-related manner carrageenan-induced paw edema in rats. Antiradical scavenging capacities of extracts and natural substances issued from Rhus tripartitum were tested using free radical forms of ABTS and DPPH. The Trolox Equivalent Antioxidant Capacity (TEAC) assay shows values of 1.92, 1.39, 1.25, 2.40, and 1.58 mM Trolox/mg sample respectively for the chloroformic extract, the ethyl acetate extract, (S1), (S2), and (S3). Values revealed form the total phenolic content assay were 299.3, 372.3, 99.1, and 235.7 mg Catechin/g extract respectively for the chloroformic, ethyl acetate, ethyl acetate/methanol, and methanolic extracts.

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Authors and Affiliations

  1. Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique 99/UR/12-26 Faculté des Sciences de Monastir, 5000, Monastir, Tunisie

    Mohamed Ali Mahjoub, Samia Ammar, Nabila Mighri & Zine Mighri

  2. Faculté de Pharmacie, Laboratoire de Pharmacologie Marine (UR. 99/UR/12-26), 5000, Monastir, Tunisie

    Abderrahman Bouraoui

  3. Laboratoire des substances biologiquement actives et des maladies transmissibles Faculté de Pharmacie, 5000, Monastir, Tunisie

    Hayet Edziri

Authors
  1. Mohamed Ali Mahjoub
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  2. Samia Ammar
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  3. Hayet Edziri
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  4. Nabila Mighri
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  5. Abderrahman Bouraoui
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  6. Zine Mighri
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Correspondence to Mohamed Ali Mahjoub.

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Mahjoub, M.A., Ammar, S., Edziri, H. et al. Anti-inflammatory and antioxidant activities of some extracts and pure natural products isolated from Rhus tripartitum (Ucria). Med Chem Res 19, 271–282 (2010). https://doi.org/10.1007/s00044-009-9190-z

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  • DOI: https://doi.org/10.1007/s00044-009-9190-z

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