Abstract
A few novel 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones were synthesized and evaluated for anticonvulsant, neurotoxicity, sedative-hypnotic, and phenobarbitone-induced hypnosis potentiation test. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight derivatives were examined in the maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ)-induced seizure models in mice. Spectroscopic data were consistence with the newly synthesized compounds. The neurotoxicity was assessed using the Rotorod method. Out of 15 compounds only 7e and 7o showed anticonvulsant activity at various doses in one or more test models. All except 7d, 7m, and 7n exhibited significant sedative-hypnotic activity via actophotometer screen. Central nervous system (CNS)-depressant activity screened with the help of the forced swim method resulted into some potent compounds. No percentage increase in the sleeping time was observed in any of the synthesized compounds evaluated by the phenobarbitone-induced hypnosis potentiation test. On the basis of experimental data, it can be concluded that synthesized compounds possessed relatively better sedative-hypnotic and CNS-depressant activities.
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Armarego WL (1963) Quinazolines. Adv Heterocycl Chem 11:253–309. doi:10.1016/S0065-2725(08)60527-9
Boissoer JR, Simon P (1965) Arch Int Pharmacodyn Ther 158:212–214
Boltze KH, Dell HD, Lehwald H, Loranz D, Ruberg-Schweer M (1963) Substituted 4-Quinazolinone derivatives as hypnotics and anticonvulsants. Arzneim-Forsch Drug Res 13:688–692
Chaurasia MR, Sharma SK (1982) Pharmacological evaluation of 2-substituted (1,3,4) thiadiazolo quinazolines. J Indian Chem Soc 59:370–376
Dimmock JR, Pandeya SN, Quail JW, Pugazhenthi U, Allen TM, Kao GY, Balzarini J, Clercq ED (1995a) Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicycylic ketones for anticonvulsant and other biological properties. Eur J Med Chem 30:303–314. doi:10.1016/0223-5234(96)88238-9
Dimmock JR, Sidhu KK, Tumber SD, Basran SK, Chen MJ, Quail W, Yang J, Rozas I, Weaver DF (1995b) Some aryl semicarbazones possessing anticonvulsant activities. Eur J Med Chem 30:287–301. doi:10.1016/0223-5234(96)88237-7
Gupta A, Mishra P, Kashaw SK, Jatav V, Stables JP (2008) Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Delta(2)-1,2,4-thiadiazoline. Eur J Med Chem 43:749–754. doi:10.1016/j.ejmech.2007.05.008
Jatav V, Mishra P, Kashaw S, Stables JP (2008a) CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. Eur J Med Chem 43:1945–1954. doi:10.1016/j.ejmech.2007.12.003
Jatav V, Mishra P, Kashaw S, Stables JP (2008b) Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. Eur J Med Chem 43:135–141. doi:10.1016/j.ejmech.2007.02.004
Kumar P, Dhawan KN, Vrat S, Bhargava KP, Kishore K (1983) Synthesis of 6-substituted 2-phenyl-3-(5-substituted mercapto-1,3,4, thiadiazol-2-yl)quinazolin-4-(3H)-ones as antitubercular agents. Arch Pharm 316:759. doi:10.1002/ardp.19833160906
Mishra P, Jatav V, Kashaw SK (2006) Some novel 2-Methyl-3-(1’3’4’-thiadiazoyl)-4-(3H) quinazolinones with anticonvulsant and CNS depressant activity. J Indian Chem Soc 83:1165–1170
Misra S, Satsangi RK, Tiwari SS (1982) Synthesis and CNS activities of some 2-alkyl-3(2-substituted indol-3-yl)-methyl, 6-substituted-quinazolin-4(3H)-ones. Pol J Pharmacol Pharm 34:441–447
Mukerji DD, Nautiyal SR, Prasad CR, Dhawan BN (1980) CNS-depressant activity of some newly synthesised 4(3H)-quinazolones. Indian J Med Res 71:480–482
Plescia S, Daidone G, Raffa D, Bajardi ML, Caruso AV (1992) Synthesis and pharmacological study of some 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones. Farmaco 47:465–475
Porsolt RD, Anton G, Blanet N, Jalbre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–386. doi:10.1016/0014-2999(78)90118-8
Saxena S, Verma M, Saxena AK, Shanker K (1992) 1,3,4-oxidiazole thiones as inflammation inhibitors. Indian J Pharm Sci 54:1–3
Swinyard EA, Clark LD, Miyahara JT, Wolf HH (1961) Studies on the mechanism of amphetamine toxicity in aggregated mice. J Pharmacol Exp Ther 132:97–102
White HS, Johnson M, Wolf HH, Kupferberg HJ (1995a) The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models. Ital J Neurol Sci 16:73–77. doi:10.1007/BF02229077
White HS, Woodhead JH, Franklin MR (1995b) General principals: experimental selection, quantification and evaluation of antiepileptic drugs. In: Antiepileptic drugs. New York, Raven Press, pp 99–110
Wolfe JF, Rathman TL, Sleevi MC, Campbell JA, Greenwood TD (1990) Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones. J Med Chem 33:161–166. doi:10.1021/jm00163a027
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The authors acknowledge the assistance of the Antiepileptic Drug Development Program, Epilepsy Branch, Preclinical Pharmacology Section, NIH, USA.
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Kashaw, S.K., Gupta, V., Kashaw, V. et al. Anticonvulsant and sedative-hypnotic activity of some novel 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazoline-4(3H)-ones. Med Chem Res 19, 250–261 (2010). https://doi.org/10.1007/s00044-009-9188-6
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DOI: https://doi.org/10.1007/s00044-009-9188-6