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Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones

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Abstract

Several 3-[5-(4-substituted)phenyl-1,3,4-oxadiazole-2-yl]-2-styryl quinazoline-4(3H)-one were synthesized and screened for antibacterial activity against Staphylococcus aureus , Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli and antifungal activity against Aspergillus niger and Fusariumoxysporum by the serial dilution technique. Compounds were prepared by reacting corresponding 2-methtyl quinazolinone and 4-subustituted benzaldehydes in glacial acetic acid. Physicochemical and spectral data were consistent with newly synthesized compounds. The prepared compounds were compared with previously synthesized 2-methyl-3-[5-(4-substituted)phenyl-1,3,4-oxadiazole-2-yl]-quinazoline-4(3H)-ones for antimicrobial activity. The present study revealed that styryl moiety at the second position of 4(3H) quinazolinone marginally increased the biological activity and exhibited better antibacterial than antifungal activities.

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Acknowledgements

Thanks are due to SAIF, Lucknow for performing spectroscopic studies.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H.S.G. University, Sagar, India

    Vivek Gupta, Sushil K. Kashaw, Varsha Jatav & Pradeep Mishra

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  1. Vivek Gupta
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  2. Sushil K. Kashaw
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  3. Varsha Jatav
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  4. Pradeep Mishra
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Correspondence to Sushil K. Kashaw.

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Gupta, V., Kashaw, S.K., Jatav, V. et al. Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones. Med Chem Res 17, 205–211 (2008). https://doi.org/10.1007/s00044-007-9054-3

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  • DOI: https://doi.org/10.1007/s00044-007-9054-3

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