Skip to main content
Log in

Two novel trichothecenes from Myrothecium roridum

  • Original Research
  • Published:
Medicinal Chemistry Research Aims and scope Submit manuscript

Abstract

Two new trichothecenes, Roridin P and Isororidin P, and two known trichothecenes, Verrucarin A and Verrucarin J, were isolated from liquid cultures of Myrothecium roridum Tale ex Fr. The stereo-structures of Roridin P and Isororidin P were established on the basis of one- and two-dimensional nuclear magnetic resonance (NMR) spectral analyses. Roridin P and Isororidin P induced morphological changes in Pyricularia oryzae, with a minimum concentration (MMCC) value of 6.2 ± 1.1 μmol/L and 7.9 ± 1.5 μmol/L.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amagata T, Rath C, Rigot JF, Tarlov N, Tenney K, Valeriote FA, Crews PJ (2003) Structures and Cytotoxic Properties of Trichoverroids and Their Macrolide Analogues Produced by Saltwater Culture of Myrothecium verrucaria. Med Chem 46:4342

    Article  CAS  Google Scholar 

  • Breitenstein W, Tamm C (1975) 13C-NMR.-spectroscopy of the trichothecane derivatives verrucarol, verrucarins A and B and roridins A, D and H. Helv Chim Acta 58:1172

    Article  PubMed  CAS  Google Scholar 

  • Iida A, Konishi K, Kubo H, Tomioka K, Tokuda H, Nishino H (1996) Potent anti-tumor promoting sesquiterpenoids from the fungus Trichothecium roseum. Tetrahedron Lett 37:9219

    Article  CAS  Google Scholar 

  • Jarvis BB, Stahly GP, Pavanasivam G, Midiwo JO, Desilva T, Holmlund CE, Mazzola EP, Geoghegan RF (1982) Isolation and characterization of the trichoverroids and new roridins and verrucarins. J Org Chem 47:1117

    Article  CAS  Google Scholar 

  • Jarvis BB, Wang S (1999) Stereochemistry of the roridins. Diasteromers of roridin E. J Nat Prod 62:1284

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi H, Namikoshi M, Yoshimoto T, Yokochi T (1996) A screening method for antimitotic and antifungal substances using conidia of Pyricularia oryzae, modification and application to tropical marine fungi. J Antibiot 49:873

    Google Scholar 

  • Wagenaar MM, Clardy J (2001) Two new roridins isolated from Myrothecium sp. J Antibiot 54:517

    PubMed  CAS  Google Scholar 

  • Wang T, Zhang Y, Qi XL, Pei YH (2001) Studies on bioactive constituents of Penicillium purpurogenum stoll. Shenyang Yaoke Daxue Xuebao 18:350

    CAS  Google Scholar 

  • Wang T, Zhang Y, Pei YH, Hua HM, Feng BM (2002) A new macrocyclic trichothecene from soil fungus. Chin Chem Lett 13:67

    CAS  Google Scholar 

  • Zhang Y, Wang T, Pei YH, Hua HM, Feng BM (2002) Aspergillin PZ, a novel isoindole-alkaloid from Aspergillus awamori. J Antibiot 55:693

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The present work was supported by Foundation of State Key Basic Research and Development Project (G1998051100), Beijing, China.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tao Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, T., Zhang, Y. & Pei, Yh. Two novel trichothecenes from Myrothecium roridum . Med Chem Res 16, 155–161 (2007). https://doi.org/10.1007/s00044-007-9012-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00044-007-9012-0

Keywords

Navigation