Skip to main content
SpringerLink
Log in

Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

  • Published:
Medicinal Chemistry Research Aims and scope Submit manuscript

Geometric cis, trans isomers, derivatives of 2-substituted-1,3-dioxanes were designed and studied as antimuscarinic agents. The synthesized compounds were evaluated as perchlorides and methiodides by functional tests with rabbit vas deferens (putative M1), guinea-pig heart (M2) and guinea-pig ileum (M3). The effect of the replacement of a trimethylammonium group with a dimethysulfonium in the two rings was also evaluated. Pharmacological results indicate that the 1,3-dioxane nucleus shows the highest stereoselective values on the studied receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, Camerino (MC), Italy, I-62032

    Gabriella Marucci, Angeli Piero, Michela Buccioni, Dario Giardinà, Ugo Gulini, Alessandro Piergentili & Gianni Sagratini

  2. Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, Modena, Italy, I-41100

    Livio Brasili

Authors
  1. Gabriella Marucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angeli Piero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Livio Brasili
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michela Buccioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dario Giardinà
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ugo Gulini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Alessandro Piergentili
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gianni Sagratini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Angeli Piero.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marucci, G., Piero, A., Brasili, L. et al. Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes. Med Chem Res 14, 274–296 (2005). https://doi.org/10.1007/s00044-005-0139-6

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00044-005-0139-6

Keywords

Search

Navigation