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PRODUCTION OF ANTIBACTERIAL AND ANTIFUNGAL METABOLITES BY STREPTOMYCES VIOLACEUSNIGER AND MEDIA OPTIMIZATION STUDIES FOR THE MAXIMUM METABOLITE PRODUCTION

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Abstract

An antibiotic producing strain Streptomyces violaceusniger was isolated from soil sample, characterized and studied for antibacterial and antifungal activity profile. Fermentation broth and cell extracts were tested against typed test organisms. The activity profiles of the intracellular and extracellular crude extracts showed that the antibiotic producing culture produces two or more compounds, one being intracellular (antifungal), other being extracellular (antibacterial). Broth extract showed activity against E. coli, bacillus subtilis, B. cereus, Pseudomonas aeruginosa and Klebsiella pneumoniae. The cell extract showed activity against Candida albicans, Aspergillus niger, Trichoderma viridae, Fusarium moniliforme and Alternaria brassicicola. Production medium was optimized for antibiotic production.

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Authors and Affiliations

  1. Fermentation Technology Division, Central Drug Research Institute, Lucknow-226001, India

    C.K.M. Tripathi, Vandana Praveen, Vineeta Singh & Vinod Bihari

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  1. C.K.M. Tripathi
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  2. Vandana Praveen
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  3. Vineeta Singh
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  4. Vinod Bihari
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Correspondence to Vinod Bihari.

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Tripathi, C., Praveen, V., Singh, V. et al. PRODUCTION OF ANTIBACTERIAL AND ANTIFUNGAL METABOLITES BY STREPTOMYCES VIOLACEUSNIGER AND MEDIA OPTIMIZATION STUDIES FOR THE MAXIMUM METABOLITE PRODUCTION. Med Chem Res 13, 790–799 (2004). https://doi.org/10.1007/s00044-004-0118-3

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  • DOI: https://doi.org/10.1007/s00044-004-0118-3

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