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Anterior pituitary development and Pit-1/GHF-1 transcription factor

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Abstract

Anterior pituitary differentiation is a well-established paradigm in mammalian organogenesis. PIT1/GHF1, a homoeotic gene, plays a key role in terminal pituitary differentiation. Recently, a new set of transcription factors involved in early pituitary differentiation have been identified Lhx-3, Lhx-4, P-OTX and Prop1. A pituitary-specific transcriptional cascade regulating a developmental programme leads to the determination of the mature cell types.

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Authors and Affiliations

  1. Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, E-28049, Madrid, Spain

    M. de la Hoya, V. Vila, O. Jiménez & J. L. Castrillo

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  1. M. de la Hoya
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  2. V. Vila
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  3. O. Jiménez
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  4. J. L. Castrillo
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Correspondence to J. L. Castrillo.

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de la Hoya, M., Vila, V., Jiménez, O. et al. Anterior pituitary development and Pit-1/GHF-1 transcription factor. CMLS, Cell. Mol. Life Sci. 54, 1059–1066 (1998). https://doi.org/10.1007/s000180050234

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  • DOI: https://doi.org/10.1007/s000180050234

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