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Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression

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Abstract

The DEAD-box protein (DBP) Dbp5, a member of the superfamily II (SFII) helicases, has multiple reported roles in gene expression. First identified as an essential regulator of mRNA export in Saccharomyces cerevisiae, the enzyme now has reported functions in non-coding RNA export, translation, transcription, and DNA metabolism. Localization of the protein to various cellular compartments (nucleoplasm, nuclear envelope, and cytoplasm) highlights the ability of Dbp5 to modulate different stages of the RNA lifecycle. While Dbp5 has been well studied for > 20 years, several critical questions remain regarding the mechanistic principles that govern Dbp5 localization, substrate selection, and functions in gene expression. This review aims to take a holistic view of the proposed functions of Dbp5 and evaluate models that accommodate current published data.

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Acknowledgements

We would like to acknowledge all past and current members of the Montpetit laboratory for their support of this work. AANR was funded by the predoctoral Training Program in Molecular and Cellular Biology at UC Davis that is supported by an NIH T32 training grant (GM007377). AANR and BM were supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM124120 (BM). The content is solely the responsibility of the authors and does not necessarily represent the views of the National Institutes of Health.

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  1. Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group, University of California Davis, Davis, CA, USA

    Arvind Arul Nambi Rajan & Ben Montpetit

  2. Department of Viticulture and Enology, University of California Davis, Davis, CA, USA

    Ben Montpetit

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Arul Nambi Rajan, A., Montpetit, B. Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression. Cell. Mol. Life Sci. 78, 2019–2030 (2021). https://doi.org/10.1007/s00018-020-03680-y

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