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The neglected part of early embryonic development: maternal protein degradation

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Abstract

The degradation of maternally provided molecules is a very important process during early embryogenesis. However, the vast majority of studies deals with mRNA degradation and protein degradation is only a very little explored process yet. The aim of this article was to summarize current knowledge about the protein degradation during embryogenesis of mammals. In addition to resuming of known data concerning mammalian embryogenesis, we tried to fill the gaps in knowledge by comparison with facts known about protein degradation in early embryos of non-mammalian species. Maternal protein degradation seems to be driven by very strict rules in terms of specificity and timing. The degradation of some maternal proteins is certainly necessary for the normal course of embryonic genome activation (EGA) and several concrete proteins that need to be degraded before major EGA have been already found. Nevertheless, the most important period seems to take place even before preimplantation development—during oocyte maturation. The defects arisen during this period seems to be later irreparable.

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Acknowledgements

Supported by Grant GACR 13-24730P and Internal Grant Agency of the Czech University of Life Sciences CIGA 20172013. This work was supported by IAPG institutional support RVO: 67985904. JK was supported by the Danish Council for Independent Research/Natural Sciences (FNU) 8021-00048B. The authors would like to thank B. J. Watson-Jones for reading the manuscript and language correction.

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  1. Laboratory of Developmental Biology, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic

    Tereza Toralova, Veronika Kinterova & Jiri Kanka

  2. Department of Veterinary Sciences, Czech University of Life Sciences in Prague, Prague, Czech Republic

    Veronika Kinterova & Eva Chmelikova

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Toralova, T., Kinterova, V., Chmelikova, E. et al. The neglected part of early embryonic development: maternal protein degradation. Cell. Mol. Life Sci. 77, 3177–3194 (2020). https://doi.org/10.1007/s00018-020-03482-2

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