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Progress on chicken T cell immunity to viruses

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Abstract

Avian virus infection remains one of the most important threats to the poultry industry. Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and infectious bursal disease virus (IBDV) are normally controlled by antibodies specific for surface proteins and cellular immune responses. However, standard vaccines aimed at inducing neutralizing antibodies must be administered annually and can be rendered ineffective because immune-selective pressure results in the continuous mutation of viral surface proteins of different strains circulating from year to year. Chicken T cells have been shown to play a crucial role in fighting virus infection, offering lasting and cross-strain protection, and offer the potential for developing universal vaccines. This review provides an overview of our current knowledge of chicken T cell immunity to viruses. More importantly, we point out the limitations and barriers of current research and a potential direction for future studies.

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Funding

This work was supported by the National Natural Science Foundation Grants (31802174 and 31830097) and a China Postdoctoral Science Foundation Grant (2018M630956).

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Authors and Affiliations

  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, People’s Republic of China

    Manman Dai, Chenggang Xu & Ming Liao

  2. T Cell Lab, Department of Biochemistry and Genetics, La Trobe Institute of Molecular Science, La Trobe University, Bundoora, Australia

    Weisan Chen

  3. National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou, People’s Republic of China

    Manman Dai, Chenggang Xu & Ming Liao

  4. Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, Guangzhou, People’s Republic of China

    Chenggang Xu & Ming Liao

  5. Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, People’s Republic of China

    Chenggang Xu & Ming Liao

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  1. Manman Dai
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MMD drafted the manuscript. WSC, ML, and CGX revised the manuscript.

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Dai, M., Xu, C., Chen, W. et al. Progress on chicken T cell immunity to viruses. Cell. Mol. Life Sci. 76, 2779–2788 (2019). https://doi.org/10.1007/s00018-019-03117-1

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