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Role of cell cycle regulators in adipose tissue and whole body energy homeostasis

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Abstract

In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.

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Acknowledgements

We thank Anita Nasrallah for critical reading of the manuscript. The Fajas lab is funded by the Swiss national science foundation (SNF).

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Authors and Affiliations

  1. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

    I. C. Lopez-Mejia, J. Castillo-Armengol & L. Fajas

  2. Department of Physiology, University of Lausanne, Lausanne, Switzerland

    I. C. Lopez-Mejia, J. Castillo-Armengol, S. Lagarrigue & L. Fajas

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  1. I. C. Lopez-Mejia
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  2. J. Castillo-Armengol
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  3. S. Lagarrigue
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  4. L. Fajas
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Correspondence to L. Fajas.

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Lopez-Mejia, I.C., Castillo-Armengol, J., Lagarrigue, S. et al. Role of cell cycle regulators in adipose tissue and whole body energy homeostasis. Cell. Mol. Life Sci. 75, 975–987 (2018). https://doi.org/10.1007/s00018-017-2668-9

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