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S100A6 protein: functional roles

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Abstract

S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6’s effects. Dosage of serum S100A6 might aid in diagnosis in oncology.

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Abbreviations

ALS:

Amyotrophic lateral sclerosis

CacyBP/SIP:

Calcyclin-binding protein/Siah-1-interacting protein

CDK:

Cyclin-dependent kinase

EGF:

Epidermal growth factor

Hsp:

Heat shock protein

IL:

Interleukin

MDM:

Transformed mouse 3T3 cell double minute

NF-κB:

Nuclear transcription factor κB

Nrf2:

Nf-E2 related factor 2

PDGF:

Platelet-derived growth factor

RAGE:

Receptor for advanced glycation end product

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

Sp1:

Specificity protein 1

TNF:

Tumor necrosis factor

TRAIL:

Tumor necrosis factor-related apoptosis-inducing ligand

USF:

Upstream transcription factor

VEFG:

Vascular endothelial growth factor

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Acknowledgements

This work was supported by Associazione Italiana Ricerca sul Cancro (Project No. Project 17581). The authors wish to thanks the reviewers for criticism and suggestions.

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  1. Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica Funzionale, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132, Perugia, Italy

    Rosario Donato, Guglielmo Sorci & Ileana Giambanco

  2. Department of Experimental Medicine, Istituto Interuniversitario di Miologia (Interuniversity Institute for Myology), Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132, Perugia, Italy

    Rosario Donato & Guglielmo Sorci

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  1. Rosario Donato
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Donato, R., Sorci, G. & Giambanco, I. S100A6 protein: functional roles. Cell. Mol. Life Sci. 74, 2749–2760 (2017). https://doi.org/10.1007/s00018-017-2526-9

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