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Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications

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Abstract

Human adipose-derived mesenchymal stem cells (hASCs) are an ideal cell source for regenerative medicine due to their capabilities of multipotency and the readily accessibility of adipose tissue. They have been found residing in a relatively low oxygen tension microenvironment in the body, but the physiological condition has been overlooked in most studies. In light of the escalating need for culturing hASCs under their physiological condition, this review summarizes the most recent advances in the hypoxia effect on hASCs. We first highlight the advantages of using hASCs in regenerative medicine and discuss the influence of hypoxia on the phenotype and functionality of hASCs in terms of viability, stemness, proliferation, differentiation, soluble factor secretion, and biosafety. We provide a glimpse of the possible cellular mechanism that involved under hypoxia and discuss the potential clinical applications. We then highlight the existing challenges and discuss the future perspective on the use of hypoxic-treated hASCs.

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Acknowledgements

The work was supported by the UM High Impact Research Grant UM-MOHE (UM.C/HIR/MOHE/ENG/44) from the Ministry of Higher Education Malaysia and the University of Malaya Research Grant (UMRG: RP040B-15HTM).

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    1. Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia

      Jane Ru Choi, Kar Wey Yong & Wan Kamarul Zaman Wan Safwani

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    Correspondence to Jane Ru Choi or Wan Kamarul Zaman Wan Safwani.

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    J. R. Choi and K. W. Yong contributed equally to this work.

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    Choi, J.R., Yong, K.W. & Wan Safwani, W.K.Z. Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications. Cell. Mol. Life Sci. 74, 2587–2600 (2017). https://doi.org/10.1007/s00018-017-2484-2

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