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Synucleinopathies: common features and hippocampal manifestations

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Abstract

Parkinson’s disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy (MSA) are three major synucleinopathies characterized by α-synuclein-containing inclusions in the brains of patients. Because the cell types and brain structures that are affected vary markedly between the disorders, the patients have different clinical manifestations in addition to some overlapping symptoms, which are the basis for differential diagnosis. Cognitive impairment and depression associated with hippocampal dysfunction are frequently observed in these disorders. While various α-synuclein-containing inclusions are found in the hippocampal formation, increasing evidence supports that small α-synuclein aggregates or oligomers may be the real culprit, causing deficits in neurotransmission and neurogenesis in the hippocampus and related brain regions, which constitute the major mechanism for the hippocampal dysfunctions and associated neuropsychiatric manifestations in synucleinopathies.

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Acknowledgements

The authors are supported by Grants from the National Basic Research Program (“973” Program) of China (2011CB504101), the Natural Science Foundation of China (81371200, 81071014, 81401042), the National Science and Technology Support Program (2012BAI10B03) and Special Scientific Research Funds for Capital Health Development (2011-1001-01), Natural Science Foundation of Beijing (7122035).

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Authors and Affiliations

  1. Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China

    Weiwei Yang & Shun Yu

  2. Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China

    Shun Yu

  3. Beijing Key Laboratory for Parkinson’s Disease, Beijing, China

    Shun Yu

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  1. Weiwei Yang
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  2. Shun Yu
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Correspondence to Shun Yu.

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Yang, W., Yu, S. Synucleinopathies: common features and hippocampal manifestations. Cell. Mol. Life Sci. 74, 1485–1501 (2017). https://doi.org/10.1007/s00018-016-2411-y

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  • DOI: https://doi.org/10.1007/s00018-016-2411-y

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