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Mechanism of ciliary disassembly

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Abstract

As motile organelles and sensors, cilia play pivotal roles in cell physiology, development and organ homeostasis. Ciliary defects are associated with a class of cilia-related diseases or developmental disorders, termed ciliopathies. Even though the presence of cilia is required for diverse functions, cilia can be removed through ciliary shortening or resorption that necessitates disassembly of the cilium, which occurs normally during cell cycle progression, cell differentiation and in response to cellular stress. The functional significance of ciliary resorption is highlighted in controlling the G1-S transition during cell cycle progression. Internal or external cues that trigger ciliary resorption initiate signaling cascades that regulate several downstream events including depolymerization of axonemal microtubules, dynamic changes in actin and the ciliary membrane, regulation of intraflagellar transport and posttranslational modifications of ciliary proteins. To ensure ciliary resorption, both the active disassembly of the cilium and the simultaneous inhibition of ciliary assembly must be coordinately regulated.

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Abbreviations

IFT:

Intraflagellar transport

MT:

Microtubule

NaPPi:

Sodium pyrophosphate

Plk1:

Polo-like kinase 1

Dvl2:

Dishevelled 2

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Acknowledgments

We thank Drs. Roger Sloboda and Kaiyao Huang for critical review and editing of this manuscript. This work was supported by awards from the National Basic Research Program of China (2012CB945000 and 2013CB910700) and the National Science Foundation of China (31330044) to J. P. Y. L is supported by a Postdoctoral Fellowship from Tsinghua-Peking Center for Life Sciences.

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  1. MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China

    Yinwen Liang, Dan Meng, Bing Zhu & Junmin Pan

  2. Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong, China

    Junmin Pan

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Correspondence to Junmin Pan.

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Liang, Y., Meng, D., Zhu, B. et al. Mechanism of ciliary disassembly. Cell. Mol. Life Sci. 73, 1787–1802 (2016). https://doi.org/10.1007/s00018-016-2148-7

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