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NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions

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Abstract

NLRs (nucleotide-binding domain, leucine-rich repeat containing receptors) are pattern recognition receptors associated with immunity and inflammation in response to endogenous and exogenous pathogen and damage associated molecular patterns (PAMPs and DAMPs respectively). Dysregulated NLR function is associated with several diseases including cancers, metabolic diseases, autoimmune disorders and autoinflammatory syndromes. In the last decade, distinct cell and organ specific roles for NLRs have been identified however; their roles in cancer initiation, development and progression remain controversial. This review summarizes the emerging role of NLRs in cancer and their possible future as targets for cancer therapeutics.

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Acknowledgments

SJ’s laboratory is funded by grants from the Department of Science and Technology (Young scientist scheme, SB/YS/LS-282/2013) and Board of Research in Nuclear Sciences (2013/36/72-BRNS/2415), Government of India. The software application Science Slides (VisiScience) was used to generate parts of Figs. 1, 2 and 3.

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  1. Department of Biology, Indian Institute of Technology Jodhpur, Old Residency Road, Ratanada, Jodhpur, Rajasthan, 342011, India

    Nidhi Sharma & Sushmita Jha

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  1. Nidhi Sharma
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  2. Sushmita Jha
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Correspondence to Sushmita Jha.

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Sharma, N., Jha, S. NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions. Cell. Mol. Life Sci. 73, 1741–1764 (2016). https://doi.org/10.1007/s00018-015-2123-8

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  • DOI: https://doi.org/10.1007/s00018-015-2123-8

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