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The code of non-coding RNAs in lung fibrosis

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Abstract

The pathogenesis of pulmonary fibrosis is a complicated and complex process that involves phenotypic abnormalities of a variety of cell types and dysregulations of multiple signaling pathways. There are numerous genetic, epigenetic and post-transcriptional mechanisms that have been identified to participate in the pathogenesis of this disease. However, efficacious therapeutics developed from these studies have been disappointingly limited. In the past several years, a group of new molecules, i.e., non-coding RNAs (ncRNAs), has been increasingly appreciated to have critical roles in the pathological progression of lung fibrosis. In this review, we summarize the recent findings on the roles of ncRNAs in the pathogenesis of this disorder. We analyze the translational potential of this group of molecules in treating lung fibrosis. We also discuss challenges and future opportunities of studying and utilizing ncRNAs in lung fibrosis.

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Acknowledgments

We apologize to colleagues whose work could not be cited due to space limitations. Sources of funding: NIH grants HL114470 (VJT), HL105473 (GL) and HL076206 (GL).

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  1. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, Birmingham, AL, 35294, USA

    Huachun Cui, Na Xie, Victor J. Thannickal & Gang Liu

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  1. Huachun Cui
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  2. Na Xie
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  3. Victor J. Thannickal
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  4. Gang Liu
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Correspondence to Gang Liu.

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Cui, H., Xie, N., Thannickal, V.J. et al. The code of non-coding RNAs in lung fibrosis. Cell. Mol. Life Sci. 72, 3507–3519 (2015). https://doi.org/10.1007/s00018-015-1939-6

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  • DOI: https://doi.org/10.1007/s00018-015-1939-6

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