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Molecular and cellular mechanisms that initiate pain and itch

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An Erratum to this article was published on 02 July 2015

Abstract

Somatosensory neurons mediate our sense of touch. They are critically involved in transducing pain and itch sensations under physiological and pathological conditions, along with other skin-resident cells. Tissue damage and inflammation can produce a localized or systemic sensitization of our senses of pain and itch, which can facilitate our detection of threats in the environment. Although acute pain and itch protect us from further damage, persistent pain and itch are debilitating. Recent exciting discoveries have significantly advanced our knowledge of the roles of membrane-bound G protein-coupled receptors and ion channels in the encoding of information leading to pain and itch sensations. This review focuses on molecular and cellular events that are important in early stages of the biological processing that culminates in our senses of pain and itch.

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Acknowledgments

This work was supported in part by grants from the National Institutes of Health RO1RGM101218, Mission Connect/the Institute for Rehabilitation and Research (TIRR) Foundation (013-108), and the Center for the Study of Itch of the Department of Anesthesiology of Washington University to H.H.

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  1. Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, 63110, USA

    Jialie Luo, Jing Feng, Shenbin Liu & Hongzhen Hu

  2. Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX, 77030, USA

    Edgar T. Walters

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  1. Jialie Luo
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  2. Jing Feng
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Correspondence to Hongzhen Hu.

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Luo, J., Feng, J., Liu, S. et al. Molecular and cellular mechanisms that initiate pain and itch. Cell. Mol. Life Sci. 72, 3201–3223 (2015). https://doi.org/10.1007/s00018-015-1904-4

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  • DOI: https://doi.org/10.1007/s00018-015-1904-4

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