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Molecular mechanism of mitochondrial calcium uptake

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Abstract

Mitochondrial calcium uptake plays a critical role in various cellular functions. After half a century of extensive studies, the molecular components and important regulators of the mitochondrial calcium uptake complex have been identified. However, the mechanism by which these protein molecules interact with one another and coordinate to regulate calcium passage through mitochondrial membranes remains elusive. Here, we summarize recent progress in the structural and functional characterization of these important protein molecules, which are involved in mitochondrial calcium uptake. In particular, we focus on the current understanding of the molecular mechanism underlying calcium through two mitochondrial membranes. Additionally, we provide a new perspective for future directions in investigation and molecular intervention.

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Acknowledgments

This work was supported by the 973 Program (Grants 2012CB917200 and 2013CB910400 to YS; Grant 2014CB910201 to XY), the Natural Science Foundation of China (Grants 31370826 to YS and 31300628 to XY), Tianjin Basic Research Program (Grant 14JCQNJ09300 to XY) and the Fundamental Research Funds for the Central Universities (Grants 65142007 to YS and 65121016 to XY).

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  1. State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin, 300071, China

    Lele Wang, Xue Yang & Yuequan Shen

  2. College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China

    Yuequan Shen

  3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300072, China

    Yuequan Shen

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  1. Lele Wang
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Wang, L., Yang, X. & Shen, Y. Molecular mechanism of mitochondrial calcium uptake. Cell. Mol. Life Sci. 72, 1489–1498 (2015). https://doi.org/10.1007/s00018-014-1810-1

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