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The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

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Abstract

The Hippo pathway was originally identified as the signaling that controls organ size in Drosophila, with the core architecture conserved in mammals. In the mammalian Hippo pathway, mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) regulate transcriptional co-activators, Yes-associated protein (YAP1) and Transcriptional co-activator with a PDZ-binding motif (TAZ). The Hippo pathway was initially thought to be quite straightforward; however, the identification of additional components has revealed its inherent complexity. Regulation of YAP1 and TAZ is not always dependent on MST1/2 and LATS1/2. MST1/2 and LATS1/2 play various YAP1/TAZ-independent roles, while YAP1 and TAZ cross-talk with other signaling pathways. In this review we focus on YAP1 and TAZ and discuss their regulation, function, and the consequences of their dysregulation.

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  1. Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan

    Manami Kodaka & Yutaka Hata

  2. Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, 113-8519, Japan

    Yutaka Hata

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Kodaka, M., Hata, Y. The mammalian Hippo pathway: regulation and function of YAP1 and TAZ. Cell. Mol. Life Sci. 72, 285–306 (2015). https://doi.org/10.1007/s00018-014-1742-9

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