References
Dekaban A (1965) Persisting clone of cells with an abnormal chromosome in a woman previously irradiated. J Nucl Med 6(10):740–746
Glover TW, Berger C, Coyle J, Echo B (1984) DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet 67(2):136–142
Durkin SG, Glover TW (2007) Chromosome fragile sites. Annu Rev Genet 41:169–192
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674
Negrini S, Gorgoulis VG, Halazonetis TD (2010) Genomic instability—an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11(3):220–228
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, McHenry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H et al (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463(7283):899–905
Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S, Andrews JM, Buck G, Chen L, Beare D, Latimer C, Widaa S, Hinton J, Fahey C, Fu B, Swamy S, Dalgliesh GL et al (2010) Signatures of mutation and selection in the cancer genome. Nature 463(7283):893–898
Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434(7035):864–870
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434(7035):907–913
Dereli-Oz A, Versini G, Halazonetis TD (2011) Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol 5(4):308–314
Halazonetis TD, Gorgoulis VG, Bartek J (2008) An oncogene-induced DNA damage model for cancer development. Science 319(5868):1352–1355
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Aqeilan, R.I. Role of common fragile sites and corresponding genes in cancer development. Cell. Mol. Life Sci. 71, 4487–4488 (2014). https://doi.org/10.1007/s00018-014-1716-y
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DOI: https://doi.org/10.1007/s00018-014-1716-y