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Metabolic circuits in neural stem cells

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Abstract

Metabolic activity indicative of cellular demand is emerging as a key player in cell fate decision. Numerous studies have demonstrated that diverse metabolic pathways have a critical role in the control of the proliferation, differentiation and quiescence of stem cells. The identification of neural stem/progenitor cells (NSPCs) and the characterization of their development and fate decision process have provided insight into the regenerative potential of the adult brain. As a result, the potential of NSPCs in cell replacement therapies for neurological diseases is rapidly growing. The aim of this review is to discuss the recent findings on the crosstalk among key regulators of NSPC development and the metabolic regulation crucial for the function and cell fate decisions of NSPCs. Fundamental understanding of the metabolic circuits in NSPCs may help to provide novel approaches for reactivating neurogenesis to treat degenerative brain conditions and cognitive decline.

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Acknowledgments

This work is supported by the Ellison Medical Foundation (AG-NS-0646-10 to J-H. P), the Weill Cornell Medical College, and the Sidney Kimmel Foundation (SKF-092 to J-H. P).

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  1. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, 10065, USA

    Do-Yeon Kim, Inmoo Rhee & Jihye Paik

  2. Department of Biochemistry, Gachon University School of Medicine, Incheon, 406-799, Korea

    Inmoo Rhee

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Kim, DY., Rhee, I. & Paik, J. Metabolic circuits in neural stem cells. Cell. Mol. Life Sci. 71, 4221–4241 (2014). https://doi.org/10.1007/s00018-014-1686-0

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