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Glutamate transporters in the biology of malignant gliomas

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Abstract

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop many biological advantages that allow them to grow and survive in the unique environment of the brain. The glutamate transporters system x −c and excitatory amino acid transporters (EAAT) are emerging as key players in the biology and malignancy of these tumors. Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival. As a consequence, malignant cells are able to quickly destroy and invade surrounding normal brain. Recent findings are painting a larger picture of these transporters in glioma biology, and as such are providing opportunities for clinical intervention for patients. This review will detail the current understanding of glutamate transporters in the biology of malignant gliomas and highlight some of the unique aspects of these tumors that make them so devastating and difficult to treat.

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Acknowledgments

This work was supported by US National Institutes of Health grants R01NS052634, 2T32NS048039, and T32GM008361. The authors would also like to thank Dr. Sue Buckingham for her help in the editing of this manuscript.

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  1. Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, CIRC 425, 1719 6th Ave S, Birmingham, AL, 35294, USA

    Stephanie M. Robert & Harald Sontheimer

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Robert, S.M., Sontheimer, H. Glutamate transporters in the biology of malignant gliomas. Cell. Mol. Life Sci. 71, 1839–1854 (2014). https://doi.org/10.1007/s00018-013-1521-z

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