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Regulation of histone gene transcription in yeast

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Abstract

Histones are the primary protein component of chromatin, the mixture of DNA and proteins that packages the genetic material in eukaryotes. Large amounts of histones are required during the S phase of the cell cycle when genome replication occurs. However, ectopic expression of histones during other cell cycle phases is toxic; thus, histone expression is restricted to the S phase and is tightly regulated at multiple levels, including transcriptional, post-transcriptional, translational, and post-translational. In this review, we discuss mechanisms of regulation of histone gene expression with emphasis on the transcriptional regulation of the replication-dependent histone genes in the model yeast Saccharomyces cerevisiae.

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Acknowledgments

Work on histone gene regulation in the Fillingham and Andrews laboratories is supported by an NSERC Discovery Grant to J.S.F. (grant number: 386646-2010) and a grant from the Canadian Institutes of Health Research (CIHR) to B.J.A. and Tim Hughes (BMB-210972). C.F.K. was supported by an EMBO long-term fellowship.

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Authors and Affiliations

  1. The Donnelly Center, University of Toronto, Toronto, ON, M5S 3E1, Canada

    Christoph F. Kurat & Brenda Andrews

  2. Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S 3E1, Canada

    Christoph F. Kurat & Brenda Andrews

  3. Natural Park, Vadhana, Bangkok, Thailand

    Judith Recht

  4. Department of Chemistry and Biology, Ryerson University, Toronto, ON, M5B 2K3, Canada

    Ernest Radovani, Tanja Durbic & Jeffrey Fillingham

  5. Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 3E1, Canada

    Brenda Andrews

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  1. Christoph F. Kurat
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  2. Judith Recht
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  3. Ernest Radovani
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  4. Tanja Durbic
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  5. Brenda Andrews
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  6. Jeffrey Fillingham
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Correspondence to Brenda Andrews or Jeffrey Fillingham.

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Kurat, C.F., Recht, J., Radovani, E. et al. Regulation of histone gene transcription in yeast. Cell. Mol. Life Sci. 71, 599–613 (2014). https://doi.org/10.1007/s00018-013-1443-9

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  • DOI: https://doi.org/10.1007/s00018-013-1443-9

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