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Multiple functions of tristetraprolin/TIS11 RNA-binding proteins in the regulation of mRNA biogenesis and degradation

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Abstract

Members of the tristetraprolin (TTP/TIS11) family are important RNA-binding proteins initially characterized as mediators of mRNA degradation. They act via their interaction with AU-rich elements present in the 3′UTR of regulated transcripts. However, it is progressively appearing that the different steps of mRNA processing and fate including transcription, splicing, polyadenylation, translation, and degradation are coordinately regulated by multifunctional integrator proteins that possess a larger panel of functions than originally anticipated. Tristetraprolin and related proteins are very good examples of such integrators. This review gathers the present knowledge on the functions of this family of RNA-binding proteins, including their role in AU-rich element-mediated mRNA decay and focuses on recent advances that support the concept of their broader involvement in distinct steps of mRNA biogenesis and degradation.

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Acknowledgments

This work was supported by Institut National de la Santé et de la Recherche Médicale (U1036), Université Joseph Fourier, Commissariat à l’Energie Atomique et aux Energies Alternatives, Association pour la Recherche sur le Cancer (ARC) and Groupement des Entreprises Françaises pour la Lutte contre le Cancer (GEFLUC-Comité Dauphiné-Savoie). DC was supported by post-doctoral grants from ARC and Fondation Lefoulon Delalande. We are indebted to Dr. Sabine Bailly for helpful discussions and friendly support.

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  1. Institut National de la Santé et de la Recherche Médicale (INSERM) U1036, 17 rue des Martyrs, 38054, Grenoble Cedex 9, France

    Delphine Ciais, Nadia Cherradi & Jean-Jacques Feige

  2. Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV)/Biologie du Cancer et de l’Infection (BCI), 38054, Grenoble, France

    Delphine Ciais, Nadia Cherradi & Jean-Jacques Feige

  3. Université Joseph Fourier-Grenoble 1, 38041, Grenoble, France

    Delphine Ciais, Nadia Cherradi & Jean-Jacques Feige

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  1. Delphine Ciais
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  2. Nadia Cherradi
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  3. Jean-Jacques Feige
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Correspondence to Jean-Jacques Feige.

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Ciais, D., Cherradi, N. & Feige, JJ. Multiple functions of tristetraprolin/TIS11 RNA-binding proteins in the regulation of mRNA biogenesis and degradation. Cell. Mol. Life Sci. 70, 2031–2044 (2013). https://doi.org/10.1007/s00018-012-1150-y

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  • DOI: https://doi.org/10.1007/s00018-012-1150-y

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