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Targeting NADPH oxidases for the treatment of cancer and inflammation

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Abstract

NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate hydrogen peroxide and superoxide, thus indicating physiological functions of these highly reactive and short-lived species. The regulation of these NADPH oxidases (nox) enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. While the complexity of the nox family (Nox1–5, Duox1, 2) is daunting, the complexity also allows for targeting of NADPH oxidases in disease states. In this review, we discuss which inflammatory and malignant disorders can be targeted by nox inhibitors, as well as clinical experience in the use of such inhibitors.

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Acknowledgments

Supported by NIAMS Grants RO1AR 47901 and RO1 AR 050727 to J.L.A, and Emory Skin Disease Research Core Center P30 AR 42687

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  1. Department of Dermatology, Emory University School of Medicine, 1639 Pierce Drive, WMB 5309, Atlanta, GA, 30322, USA

    Michael Y. Bonner & Jack L. Arbiser

  2. Atlanta Veterans Administration Medical Center, Atlanta, GA, USA

    Michael Y. Bonner & Jack L. Arbiser

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  1. Michael Y. Bonner
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Correspondence to Jack L. Arbiser.

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Bonner, M.Y., Arbiser, J.L. Targeting NADPH oxidases for the treatment of cancer and inflammation. Cell. Mol. Life Sci. 69, 2435–2442 (2012). https://doi.org/10.1007/s00018-012-1017-2

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  • DOI: https://doi.org/10.1007/s00018-012-1017-2

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