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Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98

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Abstract

The transmembrane glycoprotein CD98 is a potential regulator of multiple functions, including integrin signaling and amino acid transport. Abnormal expression or function of CD98 and disruption of the interactions between CD98 and its binding partners result in defects in cell homeostasis and immune responses. Indeed, expression of CD98 has been correlated with diseases such as inflammation and tumor metastasis. Modulation of CD98 expression and/or function therefore represents a promising therapeutic strategy for the treatment and prevention of such pathologies. Herein, we review the role of CD98 with focus on its functional importance in homeostasis and immune responses, which could help to better understand the pathogenesis of CD98-associated diseases.

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Acknowledgments

This work was supported by grants from the Department of Veterans Affairs and the National Institutes of Health of Diabetes and Digestive and Kidney by the grant RO1-DK-071594 (to D.M). We dedicate this article to the memory of Prof. Shanthi V. Sitaraman, a brilliant scientist, dedicated physician, passionate humanitarian and dearest friend.

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Authors and Affiliations

  1. M2iSH, UMR 1071 Inserm, University of Auvergne, Clermont-Ferrand, 63000, France

    Hang Thi Thu Nguyen

  2. Department of Biology, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, 30302, USA

    Didier Merlin

  3. Veterans Affairs Medical Center, Decatur, GA, 30033, USA

    Didier Merlin

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  1. Hang Thi Thu Nguyen
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  2. Didier Merlin
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Correspondence to Hang Thi Thu Nguyen or Didier Merlin.

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Nguyen, H.T.T., Merlin, D. Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98. Cell. Mol. Life Sci. 69, 3015–3026 (2012). https://doi.org/10.1007/s00018-012-0963-z

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  • DOI: https://doi.org/10.1007/s00018-012-0963-z

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