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The potter’s wheel: the host’s role in sculpting its microbiota

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Abstract

Animals, ranging from basal metazoans to primates, are host to complex microbial ecosystems; engaged in a symbiotic relationship that is essential for host physiology and homeostasis. Epithelial surfaces vary in the composition of colonizing microbiota as one compares anatomic sites, developmental stages and species origin. Alterations of microbial composition likely contribute to susceptibility to several distinct diseases. The forces that shape the colonizing microbial composition are the focus of much current investigation, and it is evident that there are pressures exerted both by the host and the external environment to mold these ecosystems. The focus of this review is to discuss recent studies that demonstrate the critical importance of host factors in selecting for its microbiome. Greater insight into host–microbiome interactions will be essential for understanding homeostasis at mucosal surfaces, and developing useful interventions when homeostasis is disrupted.

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Acknowledgments

The authors apologize that, because of the selective focus, many interesting investigations and reviews were not included. The authors’ work related to this topic was supported in part by AI57757, AI32738, AI50843, AI76246, and HD59127 from the National Institutes of Health, and by the Crohn’s and Colitis Foundation of America.

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  1. Department of Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, 95616, USA

    Charles L. Bevins

  2. Division of Gastroenterology, Department of Pediatrics, Children’s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA

    Nita H. Salzman

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  1. Charles L. Bevins
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Correspondence to Nita H. Salzman.

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Bevins, C.L., Salzman, N.H. The potter’s wheel: the host’s role in sculpting its microbiota. Cell. Mol. Life Sci. 68, 3675–3685 (2011). https://doi.org/10.1007/s00018-011-0830-3

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