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What’s the hype about CDK5RAP2?

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Abstract

Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might lead to disease in humans when the function of this protein is disturbed.

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Acknowledgments

Our research is supported by the German Research Foundation (DFG; SFB665 and IB of the BMBF), the Sonnenfeld Stiftung and the Berliner Krebsgesellschaft e.V.

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Authors and Affiliations

  1. Department of Pediatric Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany

    Nadine Kraemer, Lina Issa, Stefanie C. R. Hauck & Angela M. Kaindl

  2. Institute of Neuroanatomy and Cell Biology, Center for Anatomy, Charité, Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany

    Nadine Kraemer, Lina Issa, Stefanie C. R. Hauck, Olaf Ninnemann & Angela M. Kaindl

  3. Center for Neuroscience, Indian Institute of Science, Bangalore, 560 012, India

    Shyamala Mani

  4. Institute of Neuroanatomy and Cell Biology and Department of Pediatric Neurology, Charité, Universitätsmedizin Berlin, Center for Anatomy, Charité, Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany

    Angela M. Kaindl

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  1. Nadine Kraemer
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  2. Lina Issa
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  3. Stefanie C. R. Hauck
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  4. Shyamala Mani
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  5. Olaf Ninnemann
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  6. Angela M. Kaindl
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Corresponding author

Correspondence to Angela M. Kaindl.

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N. Kraemer and L. Issa contributed equally to this work.

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Kraemer, N., Issa, L., Hauck, S.C.R. et al. What’s the hype about CDK5RAP2?. Cell. Mol. Life Sci. 68, 1719–1736 (2011). https://doi.org/10.1007/s00018-011-0635-4

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  • DOI: https://doi.org/10.1007/s00018-011-0635-4

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