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Biology of FGFRL1, the fifth fibroblast growth factor receptor

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Abstract

FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead contains a short intracellular tail with a peculiar histidine-rich motif. The gene for FGFRL1 is found in all metazoans from sea anemone to mammals. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell differentiation. Mice with a targeted deletion of the Fgfrl1 gene die perinatally due to alterations in their diaphragm. These mice also show bilateral kidney agenesis, suggesting an essential role for Fgfrl1 in kidney development. A human patient with a frameshift mutation exhibits craniosynostosis, arguing for an additional role of FGFRL1 during bone formation. FGFRL1 contributes to the complexity of the FGF signaling system.

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Abbreviations

FGF:

Fibroblast growth factor

FGFR:

Fibroblast growth factor receptor

Ig-like:

Immunoglobulin-like

ITIM:

Immunoreceptor tyrosine-based inhibition motif

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Acknowledgments

Research in the laboratory of the author was supported by grants from the Swiss National Science Foundation (3100A-127046) and from the Swiss Foundation for Research on Muscular Diseases.

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  1. Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010, Bern, Switzerland

    Beat Trueb

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Trueb, B. Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cell. Mol. Life Sci. 68, 951–964 (2011). https://doi.org/10.1007/s00018-010-0576-3

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