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The role of deubiquitinating enzymes in apoptosis

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Abstract

It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important regulators of these processes. Cells can be subjected to various stresses and respond in a variety of different ways ranging from activation of survival pathways to the promotion of cell death, which eventually eliminates damaged cells. The regulatory mechanisms of apoptosis depend on the balanced action between ubiquitination and deubiquitination systems. There is a growing recognition that DUBs play essential roles in regulating several binding partners to modulate the process of apoptosis. Thus, the interplay between the timing of DUB activity and the specificity of ubiquitin attachment and removal from its substrates during apoptosis is important to ensure cellular homeostasis. This review discusses the role of a few ubiquitin-specific DUBs that are involved in either promoting or suppressing the process of apoptosis.

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Abbreviations

DUB:

Deubiquitinating enzyme

UPP:

Ubiquitin proteasomal pathway

USP:

Ubiquitin specific protease

UCH:

Ubiquitin carboxy terminal hydrolases

OTU:

Ovarian tumor domain

MJD:

Machado–Joseph disease

JAMM:

Jab1/MPN domain-associated metalloisopeptidase

UBDs:

Ubiquitin-binding domains

MVB:

Multivesicular body

IL:

Interleukin

IFN:

Interferon

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Acknowledgments

The authors thank members of Baek laboratory at CHA University and CHA General Hospital for their critical comments on the manuscript. This study was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (00001602).

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  1. Department of Biomedical Science, CHA General Hospital, CHA University, 606-16 Yeoksam 1-Dong, Gangnam-Gu, Seoul, 135-081, Republic of Korea

    Suresh Ramakrishna, Bharathi Suresh & Kwang-Hyun Baek

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  1. Suresh Ramakrishna
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  2. Bharathi Suresh
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  3. Kwang-Hyun Baek
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Correspondence to Kwang-Hyun Baek.

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Ramakrishna, S., Suresh, B. & Baek, KH. The role of deubiquitinating enzymes in apoptosis. Cell. Mol. Life Sci. 68, 15–26 (2011). https://doi.org/10.1007/s00018-010-0504-6

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