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Do we already know how spectrin attracts ankyrin?

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Abstract

The interaction of ankyrin and spectrin yields the major anchor between the membrane skeleton and the lipid bilayer. It is critical for red cell deformability and stability, and it is also involved in the cellular localization of several proteins, in cell differentiation, and in neuron activity. Therefore, its nature is of great interest, and recently, several researchers have had varying degrees of success in elucidating the structural basis of ankyrin–spectrin recognition. In this short paper, we briefly summarize the data obtained and compare the resulting conclusions.

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Acknowledgements

This publication was possible thanks to the financial support of the Foundation for Polish Science. We acknowledge Mr. Derek Handley for proofreading this manuscript.

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Authors and Affiliations

  1. Research and Development Centre Novasome Sp. z o.o., ul. Olsztyńska 5, 51-423, Wrocław, Poland

    Aleksander Czogalla

  2. Faculty of Biotechnology, University of Wrocław, ul. Przybyszewskiego 63/77, 51-148, Wrocław, Poland

    Aleksander Czogalla & Aleksander F. Sikorski

  3. Academic Centre for the Biotechnology of Lipid Aggregates, ul. Przybyszewskiego 63/77, 51-148, Wrocław, Poland

    Aleksander F. Sikorski

Authors
  1. Aleksander Czogalla
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  2. Aleksander F. Sikorski
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Correspondence to Aleksander F. Sikorski.

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Czogalla, A., Sikorski, A.F. Do we already know how spectrin attracts ankyrin?. Cell. Mol. Life Sci. 67, 2679–2683 (2010). https://doi.org/10.1007/s00018-010-0371-1

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  • DOI: https://doi.org/10.1007/s00018-010-0371-1

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