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Protein transport across and into cell membranes in bacteria and archaea

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Abstract

In the three domains of life, the Sec, YidC/Oxa1, and Tat translocases play important roles in protein translocation across membranes and membrane protein insertion. While extensive studies have been performed on the endoplasmic reticular and Escherichia coli systems, far fewer studies have been done on archaea, other Gram-negative bacteria, and Gram-positive bacteria. Interestingly, work carried out to date has shown that there are differences in the protein transport systems in terms of the number of translocase components and, in some cases, the translocation mechanisms and energy sources that drive translocation. In this review, we will describe the different systems employed to translocate and insert proteins across or into the cytoplasmic membrane of archaea and bacteria.

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Acknowledgments

This work was supported by the National Institutes of Health grant GM63862 (to R.E. D.), EU grants LSHM-CT-2006-019064 and PITN-GA-2008-215524, the transnational SysMO initiative through project BACELL SysMO, the European Science Foundation under the EUROCORES Programme EuroSCOPE, and grant 04-EScope 01-011 from the Research Council for Earth and Life Sciences of the Netherlands Organization for Scientific Research (to J.M.v.D.).

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  1. Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH, 43210, USA

    Jijun Yuan & Ross E. Dalbey

  2. Department of Medical Microbiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 30001, 9700 RB, Groningen, The Netherlands

    Jessica C. Zweers & Jan Maarten van Dijl

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  1. Jijun Yuan
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  2. Jessica C. Zweers
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  3. Jan Maarten van Dijl
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Correspondence to Jan Maarten van Dijl or Ross E. Dalbey.

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J. Yuan and J. C. Zweers contributed equally to this work.

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Yuan, J., Zweers, J.C., van Dijl, J.M. et al. Protein transport across and into cell membranes in bacteria and archaea. Cell. Mol. Life Sci. 67, 179–199 (2010). https://doi.org/10.1007/s00018-009-0160-x

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