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Cytoskeleton–membrane interactions in membrane raft structure

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Abstract

Cell membranes are structurally heterogeneous, composed of discrete domains with unique physical and biological properties. Membrane domains can form through a number of mechanisms involving lipid–lipid and protein–lipid interactions. One type of membrane domain is the cholesterol-dependent membrane raft. How rafts form remains a current topic in membrane biology. We review here evidence of structuring of rafts by the cortical actin cytoskeleton. This includes evidence that the actin cytoskeleton associates with rafts, and that many of the structural and functional properties of rafts require an intact actin cytoskeleton. We discuss the mechanisms of the actin-dependent raft organization, and the properties of the actin cytoskeleton in regulating raft-associated signaling events. We end with a discussion of membrane rafts and the actin cytoskeleton in T cell activation, which function synergistically to initiate the adaptive immune response.

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Acknowledgments

This work was supported by NIH grant R01 GM070001 and Oklahoma Center for the advancement of Science and Technology grants HR08-084 (WR).

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  1. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St., MS 45, Oklahoma City, OK, 73104, USA

    Gurunadh R. Chichili & William Rodgers

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  1. Gurunadh R. Chichili
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Chichili, G.R., Rodgers, W. Cytoskeleton–membrane interactions in membrane raft structure. Cell. Mol. Life Sci. 66, 2319–2328 (2009). https://doi.org/10.1007/s00018-009-0022-6

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  • DOI: https://doi.org/10.1007/s00018-009-0022-6

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