Skip to main content
SpringerLink
Log in

Rac1 GTPase: A “Rac” of All Trades

  • Visions and Reflections (Minireview)
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

Abstract.

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA

    E. E. Bosco, J. C. Mulloy & Y. Zheng

Authors
  1. E. E. Bosco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Mulloy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. Zheng.

Additional information

Received 05 September 2008; received after revision 03 November 2008; accepted 18 November 2008

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bosco, E.E., Mulloy, J.C. & Zheng, Y. Rac1 GTPase: A “Rac” of All Trades. Cell. Mol. Life Sci. 66, 370 (2009). https://doi.org/10.1007/s00018-008-8552-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s00018-008-8552-x

Keywords.

Search

Navigation