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Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway

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Abstract.

Advanced glycation end products (AGEs) play an important role in collagen deposition in diabetic cardiomyopathy. TRB3, a mammalian homolog of Drosophila tribbles, functions to increase glucose intolerance and regulates cell proliferation. We demonstrated that AGEs induce collagen type I expression but inhibit collagen type III expression, accompanied by increased TRB3 expression. Furthermore, the collagen type I induced byAGEs was down-regulated after inhibition of ERK and p38-MAPK, the collagen type III reduced by AGEs was up-regulated after inhibition of ERK. The expression of collagen types I and III regulated by AGEs through MAPK was partly reversed after treatment with TRB3 siRNA. It suggests that the TRB3/MAPK signaling pathway participates in the regulation of collagen types I and III by AGEs and may provide new therapeutic strategies for diabetic cardiomyopathy.

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Authors and Affiliations

  1. Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, P. R. China

    M. Tang

  2. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, P. R. China

    M. Tang, M. Zhong, Y. Shang, H. Jiang, H. Lu, Y. Zhang & W. Zhang

  3. Department of Cardiology, Qilu Hospital of Shandong University, Ji’nan City, Shandong Province, Jinan, P. R. China

    M. Zhong, H. Lu, Y. Zhang & W. Zhang

  4. The Second Affiliated Hospital of Fujian Medical University, Quanzhou, P. R. China

    H. Lin

  5. Department of Anatomy, Shandong University, Jinan, P. R. China

    J. Deng

Authors
  1. M. Tang
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  2. M. Zhong
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  3. Y. Shang
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  4. H. Lin
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  5. J. Deng
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  6. H. Jiang
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  7. H. Lu
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  8. Y. Zhang
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  9. W. Zhang
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Corresponding author

Correspondence to W. Zhang.

Additional information

Received 08 May 2008; received after revision 25 June 2008; accepted 22 July 2008

M. Tang, M. Zhong: These two authors contributed equally to this work.

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Tang, M., Zhong, M., Shang, Y. et al. Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway. Cell. Mol. Life Sci. 65, 2924–2932 (2008). https://doi.org/10.1007/s00018-008-8255-3

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  • DOI: https://doi.org/10.1007/s00018-008-8255-3

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