Abstract.
The epo genes of many teleosts, including zebrafish, have been cloned following the first identification of nonmammalian EPO from fugu in 2004. The zebrafish (Danio rerio) animal model is well suited for both developmental and genetic analyses for studying vertebrate erythropoiesis. The purpose of this review is to provide an update of recent progress in research on teleost EPO with a focus on its structure, expression and secretion. The EPO receptor and the downstream JAK/STAT signaling pathway are also discussed.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Additional information
Received 29 April 2008; received after revision 23 June 2008; accepted 25 June 2008
Rights and permissions
About this article
Cite this article
Chu, CY., Cheng, CH., Yang, CH. et al. Erythropoietins from teleosts. Cell. Mol. Life Sci. 65, 3545–3552 (2008). https://doi.org/10.1007/s00018-008-8231-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00018-008-8231-y