Abstract
To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
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Received 23 May 2004; received after revision 23 June 2004; accepted 25 June 2004
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Cinatl Jr., J., Hoever, G., Morgenstern, B. et al. Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. CMLS, Cell. Mol. Life Sci. 61, 2100–2112 (2004). https://doi.org/10.1007/s00018-004-4222-9
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DOI: https://doi.org/10.1007/s00018-004-4222-9