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Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis

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Abstract

Purpose

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease with synovitis as pathological changes. The immune microenvironment of RA promotes metabolic reprogramming of immune cells and stromal cells, which leads to dysfunction and imbalance of immune homeostasis. Cell metabolism undergoes the switch from a static regulatory state to a highly metabolic active state, which changes the redox-sensitive signaling pathway and also leads to the accumulation of metabolic intermediates, which in turn can act as signaling molecules and further aggravate the inflammatory response. The reprogramming of immunometabolism affects the function of immune cells and is crucial to the pathogenesis of RA. In addition, mitochondrial dysfunction plays a key role in glycolytic reprogramming in RA. These metabolic changes may be potential therapeutic targets for RA. Therefore, we reviewed the metabolic reprogramming of RA immune cells and fibroblast-like synovium cells (FLS) and its relationship with mitochondrial dysfunction.

Methods

A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning immunometabolic reprogramming, mitochondrial dysfunction, and rheumatoid arthritis.

Results

This article reviews the metabolic reprogramming of immune cells and fibroblast-like synoviocytes in RA and their relationship to mitochondrial disfunction, as well as the key pro-inflammatory pathways associated with metabolic reprogramming and chemotherapy as a potential future therapeutic strategy for RA.

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Funding

This work was supported by grants from the National Natural Science Foundation of China (81703529), Anhui Province Postdoctoral Research Activity Funding Project (2018B251), the Innovation and Entrepreneurship Project Plan of National Undergraduate Support Project of China (201910367036), and Innovative Drug Innovation Team of Bengbu Medical College (BYKC201904).

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  1. School of Pharmacy, Bengbu Medical College, Bengbu, 233030, Anhui, China

    Wei-wei Cai, Yun Yu, Shi-ye Zong & Fang Wei

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Cai, Ww., Yu, Y., Zong, Sy. et al. Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis. Inflamm. Res. 69, 1087–1101 (2020). https://doi.org/10.1007/s00011-020-01391-5

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