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“Inflammatory skin march” in atopic dermatitis and psoriasis

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Abstract

Background

Comorbidities of cardiovascular diseases (CVDs), metabolic syndrome and autoimmune diseases with systemic inflammation are recent topics in medicine. Inflammatory skin diseases such as atopic dermatitis and psoriasis are an active source of diverse proinflammatory cytokines and chemokines, which are readily detectable in the circulation and are likely to be involved in developing comorbidities.

Evidence

Both atopic dermatitis and psoriasis are frequently comorbid with CVD, metabolic syndrome and autoimmune diseases, the consequence of which is called “inflammatory skin march”, “psoriatic march” or “march of psoriasis”.

Conclusion

In this review, we summarize the epidemiological evidence and pathogenetic concepts regarding inflammatory skin march in atopic dermatitis and psoriasis.

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Fig. 1

Simplified model modified from references [42] and [44]. In addition to the disease-specific cytokine milieu in atopic dermatitis (IL-4/IL-22 axis) and psoriasis (TNF-α/IL-23/IL-17/IL-22 axis), the inflammatory skin of both diseases releases a vast range of proinflammatory cytokines such as TNF-α and IL-1 into the circulation and may cause chronic low-grade systemic inflammation. The chronic systemic inflammation induces insulin resistance, endothelial dysfunction and cardiovascular diseases. It also causes obesity, hypertension, dyslipidemia and type 2 diabetes mellitus. These systemic comorbidities further reduce the patients’ quality of life

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Authors and Affiliations

  1. Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka, 812-8582, Japan

    Masutaka Furue

  2. Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan

    Takafumi Kadono

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  1. Masutaka Furue
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Furue, M., Kadono, T. “Inflammatory skin march” in atopic dermatitis and psoriasis. Inflamm. Res. 66, 833–842 (2017). https://doi.org/10.1007/s00011-017-1065-z

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