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Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia

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Abstract

Background

Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML.

Methods and results

We determined polymorphisms of NLRP3 (rs35829419), CARD8 (rs2043211), IL-1β (rs16944), IL-18 (rs1946518) and NF-κB −94 ins/del ATTG in de novo AML patients to find out whether they play roles in the susceptibility and severity of AML. In our study, 383 AML cases and 300 randomly selected healthy individuals were examined for the polymorphisms and expression of NLRP3 genes. IL-1β (rs16944) polymorphism in different risk AML subgroups was found statistically different, with more GA genotype in favorable-risk cytogenetics group. We also demonstrated that the bone marrow blasts of patients carrying IL-18 (rs1946518) GG or GT genotype were higher than patients of TT genotype. IL-18 plasma level of patients with IL-18 (rs1946518) GT or TT genotype was higher than GG genotype. Moreover, the GT genotype of IL-18 (rs1946518) led to statistically poorer AML-specific survival.

Conclusion

IL-1β (rs16944) and IL-18 (rs1946518) may be served as potential predictors for AML.

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Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (No. 81470319, No. 81170515).

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Author notes

    Authors and Affiliations

    1. Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Rd, Jinan, 250012, People’s Republic of China

      Hong Wang, Mingqiang Hua, Jie Yu, Chen Chen, Xueyun Zhao, Chen Zhang, Chaoqin Zhong, Ruiqing Wang, Na He, Ming Hou & Daoxin Ma

    2. Department of Hematology, Zibo Central Hospital, Zibo, Shandong, People’s Republic of China

      Hong Wang

    3. Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, People’s Republic of China

      Shukang Wang

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    1. Hong Wang
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    Correspondence to Daoxin Ma.

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    Responsible Editor: John Di Battista.

    H. Wang, M. Hua and S. Wang contributed equally to this work.

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    Wang, H., Hua, M., Wang, S. et al. Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia. Inflamm. Res. 66, 249–258 (2017). https://doi.org/10.1007/s00011-016-1012-4

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