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Inflammaging: should this term be suitable for age related macular degeneration too?

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Abstract

Introduction

Inflammaging is a phenomenon triggered by the conjunction of chronic repetitive and subclinical inflammation from external aggressors and internal inflammatory mechanisms due to the progressive degradation of systems such as the mitochondrial function. Age-related macular degeneration is the leading cause of blindness and visual impairment in patients older than 60 years in developed countries.

Discussion

Remarkable correlations have been documented between common or rare immunological/inflammatory gene polymorphisms and AMD, unequivocally indicating the involvement of inflammation and immune-mediated processes (complement activation) in the pathogenesis of this disease.

Conclusion

Altogether these factors also drive this pathologic condition under the general heading of “Inflammaging”.

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Authors and Affiliations

  1. Section Ophthalmology, Department of Medical-Surgical Communication and Behaviour, University of Ferrara, Ferrara, Italy

    Carla Enrica Gallenga, Francesco Parmeggiani & Adolfo Sebastiani

  2. Department of Medicine and Health Sciences, Chair of Ophthalmology, University of Molise, Campobasso, Italy

    Ciro Costagliola

  3. University Eye Clinic, G d’Annunzio University, Chieti, PS, Italy

    Pier Enrico Gallenga

Authors
  1. Carla Enrica Gallenga
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  2. Francesco Parmeggiani
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  3. Ciro Costagliola
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  4. Adolfo Sebastiani
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  5. Pier Enrico Gallenga
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Corresponding author

Correspondence to Ciro Costagliola.

Additional information

Responsible Editor: John Di Battista.

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Gallenga, C.E., Parmeggiani, F., Costagliola, C. et al. Inflammaging: should this term be suitable for age related macular degeneration too?. Inflamm. Res. 63, 105–107 (2014). https://doi.org/10.1007/s00011-013-0684-2

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  • DOI: https://doi.org/10.1007/s00011-013-0684-2

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