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Role of Angptl4 in vascular permeability and inflammation

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Abstract

Background

Angptl4 is a secreted protein involved in the regulation of vascular permeability, angiogenesis, and inflammatory responses in different kinds of tissues. Increases of vascular permeability and abnormality changes in angiogenesis contribute to the pathogenesis of tumor metastasis, ischemic-reperfusion injury. Inflammatory response associated with Angptl4 also leads to minimal change glomerulonephritis, wound healing. However, the role of Angptl4 in vascular permeability, angiogenesis, and inflammation is controversy. Hence, an underlying mechanism of Angptl4 in different kind of tissues needs to be further clarified.

Methods

Keywords such as angptl4, vascular permeability, angiogenesis, inflammation, and endothelial cells were used in search tool of PUBMED, and then the literatures associated with Angptl4 were founded and read.

Results

Data have established Angptl4 as the key modulator of both vascular permeability and angiogenesis; furthermore, it may also be related to the progression of metastatic tumors, cardiovascular events, and inflammatory diseases. This view focuses on the recent advances in our understanding of the role of Angptl4 in vascular permeability, angiogenesis, inflammatory signaling and the link between Angptl4 and multiple diseases such as cancer, cardiovascular diseases, diabetic retinopathy, and kidney diseases.

Conclusions

Taken together, Angptl4 modulates vascular permeability, angiogenesis, inflammatory signaling, and associated diseases. The use of Angptl4-modulating agents such as certain drugs, food constituents (such as fatty acids), nuclear factor (such as PPARα), and bacteria may treat associated diseases such as tumor metastasis, ischemic-reperfusion injury, inflammation, and chronic low-grade inflammation. However, the diverse physiological functions of Angptl4 in different tissues can lead to potentially deleterious side effects when used as a therapeutic target. In this regard, a better understanding of the underlying mechanisms for Angptl4 in different tissues is necessary.

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Acknowledgments

This work was supported by the Pudong New Area Health Bureau Foundation of Shanghai PWRd2012-07, the National Natural Science Foundation of China (NO. 81270130) and the National Natural Science Foundation of China(NO.81070056).

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Authors and Affiliations

  1. Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, 40037, China

    Liang Guo, Fu-Yun Ji, Xue-Jun Lv, Xue-Ling Wu & Gui-Sheng Qian

  2. Department of Respiratory Medicine, Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China

    Shao-Ying Li

  3. Department of Respiratory Medicine, Pudong New Area Gongli Hospital, Shanghai, 200135, China

    Yun-Feng Zhao

  4. NO.324 Hospital of PLA, Chongqing, 400000, China

    Yu Zhong

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  1. Liang Guo
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  2. Shao-Ying Li
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Correspondence to Xue-Ling Wu or Gui-Sheng Qian.

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Responsible Editor: Ikuo Morita.

L. Guo and S.-Y. Li contributed equally to this work.

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Guo, L., Li, SY., Ji, FY. et al. Role of Angptl4 in vascular permeability and inflammation. Inflamm. Res. 63, 13–22 (2014). https://doi.org/10.1007/s00011-013-0678-0

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